
| The Funding Landscape for Small Biopharma Ventures, 2010-2015: Trends, strategies and priorities now available at ReportsandReports | |
| Posted for ReportsandReports by shweta on August 1st 2010 and filled under Other | |
| The funding landscape for small and mid-cap biomedical companies has changed enormously over the past two years, driven by recessive public markets and withdrawal of private equity financing. | |
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Dallas, TX: ReportsandReports announce it will carry The Funding Landscape for Small Biopharma Ventures, 2010-2015: Trends, strategies and priorities Market Research Report in its Store. Browse complete Report on: http://www.reportsandreports.com/market-reports/the-funding-landscape-for-small-biopharma-ventures-2010-2015-tr/ The funding landscape for small and mid-cap biomedical companies has changed enormously over the past two years, driven by recessive public markets and withdrawal of private equity financing. The cost of raising capital has increased, and investors have become very selective about the type of transactions they participate in. Most small biopharma ventures are struggling to raise funds and maintain enough working capital for their clinical endeavours. As with any negative development, there are greater opportunities for both buyers and sellers. This report investigates the implications of the credit crisis over the next five years and suggests strategies that can improve the chances of raising money without compromising on the inherent strengths of a company or clinical asset. The emerging trends, priorities and strategies of investors are described to help entrepreneurs target the right type of investor and communicate their value proposition in the best possible manner.
Key features of this report * The long-term and short-term implications of the credit crisis on investors and entrepreneurs seeking to raise funds from public and private markets. * Established and emerging preferences in the actual deal valuation and execution process- both at a conceptual level and in terms of specific inputs that industry professionals will need. Additional insights on the due-diligence process are also provided. * Trends associated with “conditional” investments that are better able to share the risks, uncertainties and upsides; especially relevant for alliances between large pharmaceutical companies and smaller biotechnology companies. * Insights on the negotiations between deal-makers: their focus areas, issues of concern, preferences in risk-sharing and how these preferences are reflected in the actual deal terms and conditions. Scope of this report * Facilitate communication between entrepreneurs and investors by appraising them of each others priorities, areas of concern and operational constraints. * Plan in advance by understanding how such priorities, concerns and constraints will evolve over the next five years. * Understand the role of large pharmaceutical companies in funding the clinical initiatives of small biopharma players via options-based deal structures that best resolve the conflicting incentives of the two parties. * Understand the exit strategies of healthcare investors and tailor asset valuations and negotiation points accordingly. * Use the top-line industry ‘average’ data to shape economic assessments and communication.
Key Market Issues
* IPOs are not around anymore and private equity funds are struggling to raise capital and yesteryear’s artificially suppressed rates. This has severely restricted the funding options for the majority of small-mid cap biopharmaceutical companies. * Large pharmacutical companies, with their AAA credit ratings and stable cash flows, have become the major source of funds for smaller biotechnology ventures via an array of collaborative arrangements like product licensing, co-development, etc..... * This situation has greatly improved the bargaining position of the large pharma companies, enabling them to pick and choose from a wide range of relatively lower priced assets to replenish their ailing pipelines. Key findings from this report * Existing investors are reinvesting in assets they have already committed funds to because newer investors are demanding excessively dilutive investment structures that do not favor the existing owners. * Small biotech companies are struggling to maintain working capital reserves as private equity investments have been scaled back and the IPO is no longer a feasible source of funds. * Both supply and demand-side factors are reducing the earnings potential of biopharma assets. The higher cost of raising capital has fundamentally reduced the capacity to invest in risky drug development assets. Simultaneously, budgetary pressures on healthcare spending are reducing society’s willingness to pay premium prices for therapies that offer marginal improvement. * Drug manufacturers are likely to become the primary source of funding for small-mid cap biopharma via a variety of established arrangements such a licensing/ marketing agreements, co-development, joint-ventures or M&A. * The financial crisis has not changed the geographic distribution of venture financing in any discernable manner. The US and Canada will continue to remain the hubs of biopharma innovation in the next five years.
Key questions answered
* How has the financial crisis impacted the funding environment for small-mid sized biomedical companies? What will be the short-term and long-term effects of the crisis for biopharma companies? * How do healthcare investors value opportunities in early stage biomedical assets? Are there any preferences by investor type in terms of methodologies, discount rates and cash flow projections? * What are the priorities and preferences of different types of private equity funds? What issues should entrepreneurs prepare answers for to successfully negotiate the due-diligence process of private equity investors? * How has venture financing changed in response to the credit crisis? Is there a renewed interest in some therapy areas, geographies or stages of the development lifecycle?
Table of Contents
The funding landscape for small biopharma ventures, 2010-2015 Executive Summary 10 Macroeconomic trends and implications 10 Accelerating biopharma collaboration 11 Valuing investment opportunities in small biopharma 12 Priorities and preferences of private investors 13 Top-line trends in venture financing 14 Investment choices of most active firms in 2009 14 Chapter 1 Macroeconomic trends and implications 18 Summary 18 Introduction 19 Recent events 19 Supply side factors- higher cost of capital 20 Demand side factors- Decreased earnings potential 21 Provider-level constraints 23 Patient-level implications 25 Short and long term implications 26 Non-dilutive funding in an era of excessive dilution 29 Research grants and government contracts 30 Incentives of non-profit foundations 31 Government incentives and associated initiatives 33 Issues surrounding NDF from non-profit agencies 34 Chapter 2 Accelerating biopharma collaboration 38 Summary 38 Accelerating biopharma collaboration 39 Rapidly evolving deal structures 43 De-risking R&D via options-based investing 44 Due diligence in biopharma alliances 47 Marketing agreement 49 Licensing arrangement/Product acquisition 50 Joint venture 50 Alliance/Corporate partnering 51 Outright acquisition of a company 52 Conclusions 52 Chapter 3 Valuing investment opportunities in small biopharma 54 Summary 54 Introduction 55 Valuation methods and usage 55 Discounted cash flow 56 Risk-adjusted net present value 57 Real options 57 Comparables 58 Assessing commercial potential 60 Sales potential 61 Pricing and positioning 62 Cost of commercialization 65 Chapter 4 Priorities and preferences ofprivate investors 68 Summary 68 Introduction 69 Stages of investment 69 Investors: definition, overview 72 Distinction between private equity and venture capital funds 72 Angel investors 73 Venture capital funds 74 Mezzanine investors 74 Venture investors versus buyout investors 75 Process of getting new investment 77 Term sheets 78 Type of security 79 Board representation 80 Valuation 82 Capital expenditure 83 Single versus multiple investors 84 Investor priorities in the new landscape 85 Market attractiveness and product-market-focus 86 The organization 87 Financials 87 Business plan 88 Assessment of risks 88 Intellectual property protection 89 Chapter 5 Top-line trends in venture financing 92 Summary 92 How to use this chapter 93 Definition of key terms 94 Venture financing 94 Seed 94 Start-up 94 Early stage 95 Growth/expansion capital 95 Later stage 95 Mezzanine 96 Bridge loan 96 Private placement 96 Other 96 Countries attracting the most venture financing 97 Recent trends 98 Conclusions 99 Distribution of venture financing rounds by investment stage 100 Recent trends 101 Further analysis of financing rounds by stage 103 Conclusions 105 Chapter 6 Investment choices of most active firms in 2009 108 Summary 108 Most active venture capital investors in 2009 109 Analysis of investment preferences 110 Therapeutic areas of focus 110 Investment destinations by geography 113 Stage of investments 114 Two types of venture investors 115 Corporate Venture Capital (CVC) funds 116 Emerging role of CVC in Life Sciences 116 Strategic motivations 117 Novartis Venture Fund 119 Novo A/S, Denmark 121 Independent venture capital funds 125 SV Life Sciences 125 Investment focus in 2009 125 Texas Coalition for Capital 127 Chapter 7 Appendix 129 Research methodology 129 Index 132 Browse complete Report on: http://www.reportsandreports.com/market-reports/the-funding-landscape-for-small-biopharma-ventures-2010-2015-tr/
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